Why is this drug prescribed?
Xenical blocks absorption of dietary fat into the bloodstream, thereby reducing
the number of calories you get from a meal. At the usual dosage level, it cuts
fat absorption by almost one-third. Combined with a low-calorie diet, it is
used to promote weight loss and discourage the return of unwanted pounds.
The drug is prescribed for the frankly obese and for merely overweight people
who have other health problems such as high blood pressure, diabetes, or high
cholesterol levels. Your weight status is determined by your body mass index
(BMI), a comparison of height to weight.
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Most important fact about this drug
Along with dietary fat, Xenical decreases the absorption of some fat-soluble
vitamins and beta-carotene. To compensate, you should take a multivitamin containing
vitamins A, E, D, and K once a day, at least 2 hours before or 2 hours after
taking Xenical.
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How should you take this medication?
Take a capsule of Xenical during, or up to 1 hour after, each main meal. You
should follow a nutritionally balanced, low-calorie diet that provides no more
than 30 percent of its calories from fat. If you miss a meal, or the meal contains
no fat, you can skip the accompanying dose of Xenical.
--If you miss a dose...
Resume taking Xenical at the next meal. Don't try to make up the loss with
a double dose. The extra drug won't help.
--Storage instructions...
Store at room temperature, in a tightly sealed container.
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What side effects may occur?
Side effects of Xenical are more common during the first year of treatment.
If any develop or change in intensity, inform your doctor as soon as possible.
Only your doctor can determine if it is safe for you to continue taking Xenical.
More common side effects may include:
Abdominal discomfort or pain, anxiety, arthritis, back pain, diarrhea, dizziness,
earache, fatigue, fatty or oily stools, fecal urgency or incontinence, flu,
gas with fecal discharge, gum problems, headache, increased defecation, menstrual
problems, muscle pain, nausea, oily discharge, rectal discomfort or pain, respiratory
tract infections, skin rash, sleep problems, tooth problems, urinary tract infections,
vaginal inflammation, vomiting
Less common side effects may include:
Dry skin, ear/nose/throat problems, joint disorders
Side effects that usually occur after the first year of treatment with Xenical
include: depression, leg pain, swollen feet, and tendonitis.
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Why should this drug not be prescribed?
Do not take Xenical if you suffer from "chronic malabsorption syndrome"--a
condition that prevents nutrients from passing from your stomach into your bloodstream--or
from cholestasis, a blockage in the supply of bile needed for digestion. You'll
also need to avoid Xenical if it gives you an allergic reaction.
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Special warnings about this medication
Weight loss begins within 2 weeks and continues for 6 to 12 months. The effect
of using Xenical for more than 2 years is still unknown.
Side effects such as diarrhea and abdominal pain may be worse if you continue
eating a high fat diet or even take a high-fat meal. Limit your fat intake.
Your doctor will test your thyroid function before starting you on Xenical
to make sure that your weight problem is not due to an underactive thyroid gland
(hypothyroidism). Xenical is not an appropriate remedy for this problem.
Xenical increases the likelihood of kidney stones. Use it with caution if you
have a history of this problem.
If you have diabetes, weight-loss is likely to reduce your blood sugar levels.
If you're taking an oral diabetes medication or insulin, your dose may have
to be reduced.
Note that the safety and efficacy of this drug in children have not been established.
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Possible food and drug interactions when taking this medication
If Xenical is taken with certain other drugs, the effects of either could be
increased, decreased, or altered. It is especially important to check with your
doctor before combining Xenical with the following:
Cyclosporine (Neoral and Sandimmune)
Warfarin (Coumadin)
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Special information if you are pregnant or breastfeeding
The effects of Xenical during pregnancy have not been adequately studied and
the drug is not recommended for pregnant women. If you are pregnant or plan
to become pregnant, inform your doctor immediately.
It is not known whether Xenical appears in breast milk. Do not take it while
breastfeeding.
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Recommended dosage
ADULTS
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The recommended dose is one 120-milligram capsule 3 times daily with each main
meal containing fat.
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Overdosage
The results of a massive overdose of Xenical are unknown, although the drug
seems relatively harmless. However, any medication taken in excess can have
serious consequences. If you suspect an overdose, seek medical attention.
