Diclofenac Sodium/ Paracetamol Tablets
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Introduction
Paracetamol has a prominent analgesic and antipyretic effects. It works with a minimal anti-inflammatory action with no clinical significance. The mechanism of this relates with depression of thermoregulatory center in the medulla oblongata and depression of prostaglandin synthesis through inhibition of certain cell cyclooxygenase.
Composition
Each tablet contains 500 mg of active paracetamol ingredients with sodium metabisulphite that can cause allergic reactions to some patients especially to those with asthma or allergy.
Use
Paracetamol tablet is use as an over-the-counter pain reliever or analgesic and fever reducer. Commonly, it aids the headache, numerous colds, flu, little pains and aches. It becomes a great ingredient too in many medicinal products.
Dosage and administration
It is generally safe with recommended doses of 1, 000 mg for every single dose up to 3, 000 mg for an adult per day. It reaches up to 2, 000 mg each day if the person is drinking alcohol. It is a must to follow the recommended intake of this drug medicine for it can cause a potential severe liver damage and only seldom individuals can take the normal dose can have it with high risk when taken with alcohol consumption. Intoxication on paracetamol can lead to acute liver failure, proof of this is now happening in western worlds with overdoses cases in UK, US, New Zealand and Australia. Available tablets of UK Paradote in combination with paracetamol and methioninefor protection of a patient’s liver in case of an overdose. Adults must take 1 tablet with three to four times daily. Adult’s treatment must take up to 10 days.
Contraindication
Patients with liver disease and hypersensitivity on this drug tablet must never use this medicine.
Important Precautions
Patients with renal and liver disease must have the observance of extra care and attention. Using the treatment of paracetamol can affect the blood glucose analysis and laboratory tests of uric acid. The interval between consecutive takings must never on shorter 8 hours for a patient with renal failure. This medicine is not advisable for the treatment and preparation in the first trimester of the pregnancy. Nursing mothers taking this drug must have a good monitoring and observation.
Side effects
Long term use of this medicine can increase the risk on gastrointestinal complications like stomach bleeding and can cause liver or kidney damage. Side effects are more likely for patients with chronic alcoholics with liver failure.
storage
Store the tablets in a dry container and keep it in a cool, dry place with a temperature below 250C in its original package. Keep this medicine away from the children.
Paracetamol possesses prominent antipyretic and analgesic effects. Its anti-inflammatory activity is weak and has no clinical significance. The mechanism of action is related to depression of the prostaglandin synthesis by inhibition of the specific cell cyclooxygenase, and depression of the thermoregulatory center in the medulla oblongata.
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