Diabetes :: Glibenclamide Generic

Glibenclamide Generic

US Brand Name Glyburide
Generic Name Glibenclamide
Other Brand NameSemi-Daonil
Manufacturer AVENTIS, Otsira Genetica
Packing 10
Form Tablet
Strength 5 mg, 2.5 mg
 
2.5 mg $0.19
5 mg $0.29
1.25 mg $0.23
Quantity Tablet
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Introduction

Glyburide is a medication that functions by controlling the sugar level in the blood. This medicine is use to treat non insulin dependent diabetes mellitus or type 2 diabetes mellitus. This drug is manufactured by Aventis and Otsira Genetica. The generic name of this medication is glibenclamide. Other popular brand name for this drug is Semi-Daonil.

Composition

This is a crystalline compound that is white in color. Inactive components of this drug are dibasic calcium phosphate, sodium alginate, magnesium stearate, and talc. This has a molecular weight of 493.99. The drug is administered orally and comes in the strength of 1.5 mg, 3 mg, and 6 mg. It has a molecular formula of C23H28CIN305S.

Use

This medication is primarily use to improve the condition of patient with non insulin dependent diabetes mellitus or type 2 diabetes mellitus by means of glycemic control improvement.

Dosage and administration

The recommended initial dose for this drug is glyburide 2.5 mg to 5 mg a day to be given with meal preferably during breakfast. However, patient receiving insulin can also use this drug but the starting dose is 2.5 mg only. The patient can be place on glyburide therapy directly if the patient is receiving total insulin of 20 units to 40 units. For maintenance therapy, the recommended dosing would be 1.25 mg to 0 mg daily. Low dose of glyburide will be given to patient receiving 40 units and above of insulin therapy.

Contraindication

The drug treatment is contraindicated to patient with known hypersensitivity reaction to glyburide and any of its content. This is also prohibited to be use by patient with diabetic ketoacidosis and patient with insulin dependent diabetes mellitus.

Important Precautions

Special precautionary measures are given to patient with hypoglycaemia as this worsens when taking any sulfonylureas like glyburide. It is of great important to follow health care provider’s order in regards to the usage of the drug to prevent any further disease condition. Observe for signs and symptoms of hymolytic anemia while under this therapy. If you are under this treatment regimen and you got pregnant, it is advice that you contact your health care provider immediately to discuss safety measures with the use of this medication. A precautionary measure is also important in lactating mothers. Studies showed that some of the sulfonylureas are excreted in the breast milk. Blood sugar level should be check from time to time when undergoing this treatment. This drug should be used with extra caution to patient with problems in their kidney function, liver function, and elderly patient.

Side effects

The most reported common side effects of using this medication are nausea with or without vomiting, bloated feeling, weight gain, jaundice or yellowing of the skin, and heartburn. Serious side effects that prompt medical care right away are severe allergic like reaction such as formation of itchy rash all over the body, chest tightness, appearance of blister, fainting, fever with chills, swelling of the facial structure, bleeding in the gums and in the stool, and easy fatigability.

storage

Place or keep the medication in its original container. See to it that it is tightly closed. Do not place inside the bathroom. Keep away from heat, moisture, and direct sun light. Avoid the medication to be in contact of children.
 

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